What’s Closed In Tier 4 Covid Lockdown? Listing Of Shops And Businesses Compelled To Close Under New Guidelines
The plasticity of immune cells and the balance between pro-inflammatory and anti-inflammatory signals are crucial aspects of environment friendly tissue restore. Immune parts and pathways are involved in regeneration as properly, for instance in amphibians.
Individual plant cells reply to molecules associated with pathogens often known as pathogen-related molecular patterns or PAMPs. When a part of a plant turns into contaminated, the plant produces a localized hypersensitive response, whereby cells at the website of infection bear rapid apoptosis to stop the spread of the disease to different parts of the plant. Systemic acquired resistance is a kind of defensive response utilized by vegetation that renders the entire plant proof against a particular infectious agent.
Thenational restriction guidancehas been up to date with some additional data and clarifications. Please see some areas that would be of curiosity to tourism companies. Advice for UK visa applicants and short-term UK residentshas been updatedto clarify that abroad providers and in-nation immigration providers will remain open, but depending on native country restrictions. Also, the interval for requesting distinctive assurance has been extended when making use of to enter the UK or remain on the idea of family or private life. Restaurants and bars inside guest lodging ought to stay closed although food and/or drink including alcohol can be offered through room service so long as it is ordered by telephone or on-line. Communal spaces corresponding to lounges or lobbies might stay open to friends but no food or drink ought to be served in these areas, folks must be encouraged not to gather and social distancing must be noticed. Should not deliberately facilitate bookings that don’t adhere to authorities restrictions.
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One class of non-self molecules are called antigens and are outlined as substances that bind to specific immune receptors and elicit an immune response. The immune system protects its host from an infection with layered defenses of increasing specificity. Physical obstacles forestall pathogens such as micro organism and viruses from coming into the organism. If a pathogen breaches these barriers, the innate immune system offers an immediate, however non-particular response.
In the meantime guidance on the restrictions that might be relevant in every tier has been published. The Christmas Support Payment is for moist-led pubs that have been severely impacted over the festive season because of momentary native restrictions.
The different cells concerned in the innate response embrace innate lymphoid cells, mast cells, eosinophils, basophils, and natural killer cells. A scanning electron microscope picture of normal circulating human blood. One can see red blood cells, a number of knobby white blood cells including lymphocytes, a monocyte, a neutrophil, and lots of small disc-shaped platelets. Microorganisms or toxins that successfully enter an organism encounter the cells and mechanisms of the innate immune system.
Tesco have been criticised for aggressively pursuing critics of the corporate in Thailand. Writer and former MP Jit Siratranont faced up to two years in jail and a £sixteen.4 million libel damages claim for saying that Tesco was increasing aggressively on the expense of small native retailers. Tesco served him with writs for criminal defamation and civil libel. The Thai court docket dismissed the case, ruling that the criticism made by the defendant was ‘in good religion by way of truthful touch upon any individual or factor subjected to public criticism’. According to Citigroup retail analyst David McCarthy, ” pulled off a trick that I’m not conscious of any other retailer reaching. That is to appeal to all segments of the market”. help company known as The PC Guys in 2007, and were in a position to launch Tesco Tech Support in December 2008. It was introduced in March 2017 that Trevor Masters, International Chief Executive, can be leaving in May after 38 years with the company.
Something else to pay attention to is that each agency delivers to different components of Essex and surrounding areas, together with North East London, so verify your location is roofed to keep away from disappointment. Some corporations might deliver outside their usual delivery space if you’re preprepared to pay a delivery surcharge, make a big order or if they’ve obtained drivers out there, so it’s at all times price phoning to examine, even if you’re outside their said protection area. mySociety is a registered charity in England and Wales and a limited firm .
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Kennards – Opened by Debenhams as a branch of Kennards of Croydon; renamed Debenhams 1973. Re-opened as the Houndsditch earlier than closing in 1984 and being demolished and replaced by Aylesham Centre. Howards – Bought by United Drapery Stores; later integrated into the John Blundell group; renamed John Blundell. George Hitchcock Williams & Co. (St Paul’s Churchyard, London) – Established 1841; closed 1984. Main buildings demolished and website redeveloped as Orchards Shopping Centre. Havens Opened 1901; Store closed in 2017 and moved to being an online retailer solely. George Henry Havelock – Destroyed by hearth 18 July 1898; rebuilt 1900; closed 1914.
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This eveningPrime Minister, Boris Johnson gave a briefingon the most recent COVID-19 measures. During his assertion the Prime Minister introduced thatGreater Manchester will move to the ‘Very High’ local alert levelfrom midnight on Thursday 22 October. Liverpool City Region’s tier-three restrictionswill be up to date to align with these in Lancashire from Friday 23 October 2020. This signifies that gyms will be allowed to reopen and gentle play areas will shut. People should aim to reduce the number of journeys they make the place potential; if they should travel, they need to stroll or cycle where potential, or plan ahead and keep away from busy instances and routes on public transport. People should not meet in a bunch of greater than 6 exterior, together with in a backyard or different house.
The Government has introduced the resumption of the easement of restrictions from 15 August. Some of remaining features of England’s culture, sport, leisure and business sectors shall be permitted to reopen from Saturday in England – aside from particular areas where local restrictions are in place – as follows.
The grant is for companies that pay business charges on their premises. Local councils may at their discretion also present funding for businesses that don’t pay enterprise charges. The Job Support Scheme might be expanded to assist businesses throughout the UK who’re legally required to close their premises because of native or national coronavirus restrictions. Cafes and occasional shops are treated as restricted businesses for the purposes of the brand new local alert level laws (the same as restaurants, bars & pubs etc). The expanded Job Support Scheme offers momentary help to businesses whose premises have been legally required to close as a direct results of Coronavirus restrictions set by one or more of the 4 governments of the UK.
The increase in e-cigarette use, particularly amongst younger individuals, is a harmful pattern with actual well being dangers. For many causes, e-cigarettes should not be promoted as a secure different to smoking.
If a lodge has totally different venues within it, such as a restaurant or bar, separate QR code posters should be displayed in each of these. Guests can examine into these areas allowing them to be despatched notifications with public well being recommendation if needed. Customers eating and ingesting in the outdoor setting should not collect in teams of greater than 6 people. Where there is no seating available, the stall or outlet might be offering a take away service.
Offensive elements of the immune methods are additionally present in unicellular eukaryotes, however research of their roles in protection are few. Claims made by entrepreneurs of assorted products and various health providers, such as chiropractors, homeopaths, and acupuncturists to have the ability to stimulate or “increase” the immune system usually lack meaningful explanation and evidence of effectiveness. The immune response may be manipulated to suppress unwanted responses resulting from autoimmunity, allergy, and transplant rejection, and to stimulate protective responses towards pathogens that largely elude the immune system or cancer. Inflammation is one of the first responses of the immune system to infection, however it can appear without known trigger. During wake intervals, differentiated effector cells, corresponding to cytotoxic pure killer cells and cytotoxic T lymphocytes, peak to elicit an efficient response in opposition to any intruding pathogens.
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The revenue overstatement was subsequently revised upwards to £263 million following an investigation by the accountancy agency Deloitte, and it was clarified that the inflated revenue determine was the result of Tesco bringing ahead rebates from suppliers. The Serious Fraud Office confirmed on 29 October 2014 that it was carrying out a felony investigation into the accounting irregularities but declined to provide additional details. Three executives charged with fraud and false accounting in reference to the misreporting have been cleared of the fees in 2018–2019. Euphorium Bakery opened a concession in Tesco’s Kensington store in 2012, and in 2013 Tesco bought a stake within the enterprise. In August 2016, Tesco bought Euphorium’s high avenue shops and manufacturing unit in Islington to Soho Coffee, and its factory in Weybridge to Samworth Brothers. In 2012, Tesco invested in a brand new coffee shop chain, named Harris + Hoole after coffee-loving characters in Samuel Pepys’ diary.
Weddingsandfuneralscan go ahead with restrictions on the number of attendees – 15 folks can attend wedding ceremony ceremonies, marriage ceremony receptions aren’t allowed, 30 folks can attend funeral ceremonies, 15 folks can attend linked commemorative events. Weddings and funerals can go forward with restrictions on numbers of attendees – 15 people can attend wedding ceremony ceremonies and receptions, 30 people can attend funeral ceremonies, and 15 people can attend linked commemorative occasions. This afternoonPrime Minister Boris Johnson gave a statementto the House of Commons on theGovernment’s COVID-19 Winter Plan. The Prime Minister confirmed that the national restrictions in England will finish on 2 December and that the nation will move again right into a regional tiered strategy. On Thursday 26 November the federal government is due to announce which areas are in which tier.
- The co-operative continues to function numerous companies exterior of non-meals retail.
- Many corporations offering on-demand alcohol open within the evening, proper through to the early hours of the next morning.
- If the lodging supplier agrees, friends might extend their keep in order to self-isolate until they’re properly enough to travel.
The new NHS COVID-19 app is now available to download at no cost in England and Wales and is the quickest way to see if you or your small business are at risk from coronavirus. TheSelf-Employment Income Support Schemevideo steering has been up to date with data on the way to claim the second grant. We have obtained several queries from business round particulars in the guidance, please see beneath some clarifications DCMS has shared with us you may discover helpful. From midnight on 30 September, measures shall be introduced into legislation proscribing inter-family mixing in indoor settings, including pubs and eating places, in Durham, Gateshead, Newcastle, North Tyneside, South Tyneside, Northumberland and Sunderland. New restrictions have come into force in Leeds, Blackpool, Wigan and Stockport.
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Weddings, receptions, funerals, and commemorative events including wakes can proceed with up to 30 attendees. Controlled indoor events of as much as 1,000 folks or 50% of a venue’s capability, whichever is decrease, will be permitted, as will outdoor occasions with a capability of both 50% or four,000 people, whichever is lower. Some giant events, together with conferences, theatre and concert performances and sports activities events. People will be allowed to spend time in outdoor public spaces for recreation on their own, with one different person, or with their family or assist bubble. People must continue to take care of social distance from these outside their family. This is in addition to outdoor train which is already permitted.
Acquired by House of Fraser 1969; renamed Dingles 1973; renamed House of Fraser 2000s.Brights – Opened within the former premises of Bobby & Co. as a branch of Brights 1932. Subsequently, acquired by House of Fraser 1969; renamed Dingles 1973; closed Nineteen Nineties.
Cash support for food redistribution during the coronavirus outbreak to forestall meals waste. A new Coronavirus Large Business Interruption Loan Scheme will present a authorities guarantee of eighty% to allow banks to make loans of as much as £25 million to firms with an annual turnover of between £forty five million and £500 million. Updated steering on the COVID-19 Statutory Sick Pay Rebate Scheme has been made available. This scheme permits small and medium-sized employers, with fewer than 250 workers, to apply to HMRC to get well the costs of paying Statutory Sick Pay to their employees. HMRC has published Vape Shops In Derby on-line steerage which incorporates details about who can use the scheme and the data employers must keep. Read extra about the eligibility extensionandhow to assert assist through the scheme right here. Raab acknowledged that folks had been eager for dates and plans, however said it was too soon to evaluate the evidence.
People should not socialise with anybody they do not stay with, or have fashioned a help bubble with, in any indoor setting or in any personal backyard or at most outdoor hospitality venues and ticketed events. Lancashirewill transfer from local COVID alert degree excessive to very excessive on Saturday 17 October. The local COVID alert level very excessive will take impact throughout all components of Lancashire including, Burnley, Blackburn with Darwen, Blackpool, Chorley, Fylde, Hyndburn, Lancaster, Pendle, Preston, Ribble Valley, Rossendale, South Ribble, West Lancashire, Wyre. Greater Manchester will obtain £22 million of funding, in addition to funding already supplied to local authorities in England to assist them. South Yorkshirewill transfer from native COVID alert stage high to very high.
These cells don’t have any cytotoxic exercise and don’t kill infected cells or clear pathogens instantly. They instead management the immune response by directing different cells to perform these tasks. The cells of the adaptive immune system are particular forms of leukocytes, referred to as lymphocytes. B cells and T cells are the main types of lymphocytes and are derived from hematopoietic stem cells in the bone marrow. B cells are concerned within the humoral immune response, whereas T cells are involved in cell-mediated immune response. Killer T cells solely acknowledge antigens coupled to Class I MHC molecules, whereas helper T cells and regulatory T cells solely recognize antigens coupled to Class II MHC molecules. These two mechanisms of antigen presentation replicate the completely different roles of the 2 forms of T cell.
See the steerage and restrictions for areas the place the Local COVID Alert level is Very High. People ought to try to keep away from travelling exterior the ‘Very High’ space they’re in, or getting into a ‘Very High’ space, aside from for issues like work, education, accessing youth providers, to fulfill caring duties or if they’re in transit. See the guidance and restrictions for areas where the Local COVID Alert stage is High. Most areas that are already topic to local restrictions will mechanically move into the “high” alert stage. As a result of rising infection ratesNottinghamshire, East and West Cheshireand asmall space of High Peakwill additionally move into the “high” alert level.
The G20 Tourism Ministers held a gathering on COVID-19 on Friday 24 April, Tourism Minister Nigel Huddleston was in attendance and addressed the group. He spoke of the significance of tourism to the UK economic system, the Government’s help measures and the regular discussions he’s in with the tourism trade about what their priorities are for the recovery interval. He highlighted the key areas of concern including how businesses can operate while there are still social distancing measures in place; what additional steering is required; and whether there is a need for tapered help as businesses regulate. The two metre social distancing rule shall be relaxed to at least one metre plus. Where it’s attainable to remain two metres you must continue to do so, however where this isn’t potential it must be a ‘one metre plus’ policy.
Key reductions included over 1 / 4 of its workers in Welwyn Garden City and Hatfield, and the closure of the decision centre in Cardiff. The firm started to increase the range of merchandise it sold during the 1960s to include household goods and clothes under the Delamare model, and in 1974 opened its first petrol station. On 21 March 1997, Tesco announced the purchase of the retail arm of Associated British Foods, which consisted of the Quinnsworth, Stewarts and Crazy Prices chains in Ireland and Northern Ireland, and associated companies, for £640 million. The deal was permitted by the European Commission on 6 May 1997. Tesco has expanded globally since the early Nineties, with operations in eleven different nations in the world. The company pulled out of the US in 2013, however as of 2018 continues to see progress elsewhere.
No shops are permitted to sell alcohol within the area and there are not any pubs, bars or fast-meals retailers in Bournville because of its Quaker roots. In June 2008, the government announced that it was closing a tax loophole being used by Tesco.
Eldred Sayers & Sons – Bought by Bentalls; renamed Bentalls; relocated. Rankin & Co. – Bought by Benzie & Miller; renamed Benzie & Miller. Acquired by House of Fraser 1958; renamed Arnotts Seventies; closed Nineteen Eighties. Acquired by House of Fraser 1975; renamed Chiesmans 1975; renamed Army & Navy; closed Nineteen Nineties. Nicholsons (Bromley; beforehand St Paul’s Churchyard, London) – Bought by Debenhams; St Paul’s Churchyard buildings destroyed by bombing; relocated to former cinema building in Bromley; renamed Debenhams 1973; closed Nineties.
His business expanded rapidly, and by 1939 he had over 100 Tesco retailers throughout the nation. Woolland Brothers – Established 1869; new building accomplished 1901. Woodard’s Opened 1908 on nook of Regent Street and the Parade. Store was closed by then house owners Merchant Retail on the thirty first July 2004, contributing £300,000 revenue to the group.
Ribonucleases and the RNA interference pathway are conserved across all eukaryotes, and are thought to play a role within the immune response to viruses. Some tumors evade the immune system and go on to turn into cancers. Tumor cells often have a reduced variety of MHC class I molecules on their surface, thus avoiding detection by killer T cells. Some tumor cells additionally release merchandise that inhibit the immune response; for example by secreting the cytokine TGF-β, which suppresses the exercise of macrophages and lymphocytes. In addition, immunological tolerance could develop against tumor antigens, so the immune system not assaults the tumor cells. The major response of the immune system to tumors is to destroy the irregular cells utilizing killer T cells, generally with the help of helper T cells.
Pearsons was bought to Morleys Stores in 2010, with the Bishop Stortford store closed in 2012. Lincolnshire Co-operative – operated a variety of department shops, the remaining two of which, in Lincoln and Gainsborough, were acquired by Oldrids in 2013. The co-operative continues to function a number of companies outside of non-food retail. Unlike animals, plants lack phagocytic cells, but many plant immune responses involve systemic chemical alerts which are despatched by way of a plant.
New steering will be printed to support companies – together with altering workplace layouts, protecting screens, closing non-important communal areas and so forth. Guidance on closing certain businesses and venues in England has been updated following the additional easing of coronavirus restrictions from 4 July, as well as location-specific steerage for closing companies in Leicester.
We provide business providers by way of our wholly owned subsidiary SocietyWorks Ltd . In March 2015 an arson attack gutted a brand new Tesco Express store in Godalming, Surrey, two days before it was because of open. Tesco had bought a public home and transformed it to the new retailer, a change which didn’t require planning permission, thus denying the vigorous native opposition any formal technique of preventing it. After continuing native opposition, including the local MP and borough council, Tesco deserted its plans for the shop in January 2017. Tesco made a dedication to corporate social responsibility within the type of contributions of 1.87% in 2006 of its pre-tax earnings to charities and local community organisations.
Subsequently, acquired by House of Fraser 1972; renamed Binns; closed c. Acquired by House of Fraser 1957; closed 1968; reopened as Dickins & Jones on completion of new building 1970; renamed House of Fraser 2007. Acquired by House of Fraser 1976; renamed Dingles; closed Eighties. Gamis’s – established in 1828 by Ince Gamis as ‘perfumer, hairdresser and toy vendor’ and traded successively as Ince Gamis, Gamis & Hunt, Gamis & Co. and Gamis’s. The enterprise came to be owned by House of Fraser within the 1970s (probably by way of a bigger acquisition?) and was renamed Dingles earlier than closing within the 1980s. John Falconer & Co. – Bought by Scottish Drapery Corporation 1929. Acquired by House of Fraser 1952; renamed Frasers 1970s; closed 2002.
Neutrophils are usually found in the bloodstream and are probably the most plentiful type of phagocyte, representing 50% to 60% of whole circulating leukocytes. During the acute phase of inflammation, neutrophils migrate toward the site of irritation in a course of referred to as chemotaxis, and are usually the primary cells to arrive on the scene of infection. The information on this page accommodates general details about the Government’s COVID-19 steering and rules, as related to businesses, and has been provided in good religion. eleven March – In the2020 budget, the UK Government announced help for companies affected by COVID-19. 22 March – The Government has introduced the launch of the enterprise help measures outlined last week. As a part of this, they have additionally launched a dedicated business website that collates data on the support obtainable for businesses. Updated information on the closing sure businesses and venues page around compliance.
Updated guidanceis out there to assist employers calculate employees’ working and furloughed hours for employees who got here off furlough partway by way of a declare interval. Employers using this calculation do not have to amend earlier claims. Reviewwhat individuals can and may’t do, and notice that places impacted bylocal lockdown measuresmay be subject to different guidelines. Following the launch of the new COVID-19 app, clients and visitors in England will have the ability to examine-in on entry with their telephone as an alternative of filling out a examine-in guide or software particular to a business. This will allow NHS Test and Trace to contact customers with public health advice ought to there be a COVID-19 outbreak. Businesses who are already utilizing their very own QR system are being inspired to switch to the NHS Test and Trace QR code.
Attwoods – purchased by Kay & Co. of Worcester, the catalogue enterprise within the Fifties. Fear Hill – group of 4 department stores; the Trowbridge retailer was established in 1880. Allders Department Stores – group went into administration on 29 January 2005. The flagship Croydon store continued to commerce independently after 2005, lastly closing on 22 September 2012. In the case of department retailer groups, the location of the flagship retailer is given. This listing does not embody large specialist shops, which sometimes resemble department stores.
Leicester-particular guidance for social distancing during a neighborhood lockdown has additionally been up to date. Business conferences and occasions of over 30 individuals shouldn’t at present happen in conference centres and exhibition halls.
Weddings and civil partnership ceremonieswill not be permitted to take place except where a kind of getting married is seriously sick and not anticipated to recuperate (‘deathbed wedding’). A newgraphical posterdisplaying details about the national restrictions in England is on the market to obtain. Are currently in that lodging on the time when nationwide restrictions come into drive. Roofed historic buildings and totally-enclosed areas might be closed, although their attached grounds, together with automobile parks, bogs and outside play areas, can remain open.
By 2014, the number of Homeplus shops in the United Kingdom had reached 12; the latest shop opened in Chester in July 2009. In 2012 it was reported that Tesco was trying to close the business to give attention to groceries. Tesco closed six Homeplus shops on 15 March 2015, and the remaining six shops closed on 27 June 2015. Hurst & Sandler – principally a producer of robes and other textile items. The firm owned numerous subsidiary wholesale and retail material companies in Yorkshire, together with Willis Brothers of Hull and Ludlows of Bradford , John Banner of Sheffield, Lingards of Bradford and Rushworths of Huddersfield. Neutrophils and macrophages are phagocytes that travel all through the body in pursuit of invading pathogens.
A third, minor subtype are the γδ T cells that recognize intact antigens that aren’t certain to MHC receptors. The double-constructive T cells are uncovered to a wide variety of self-antigens in the thymus, during which iodine is critical for its thymus development and activity. In distinction, the B cell antigen-specific receptor is an antibody molecule on the B cell surface and recognizes native antigen without any want for antigen processing. Such antigens could also be giant molecules found on the surfaces of pathogens, however can be small haptens hooked up to service molecule. Each lineage of B cell expresses a unique antibody, so the complete set of B cell antigen receptors symbolize all of the antibodies that the physique can manufacture. When B or T cells encounter their related antigens they multiply and lots of “clones” of the cells are produced that focus on the same antigen.
Bacteria typically overcome physical limitations by secreting enzymes that digest the barrier, for instance, through the use of a kind II secretion system. Alternatively, utilizing a sort III secretion system, they could insert a hole tube into the host cell, providing a direct route for proteins to maneuver from the pathogen to the host. Evolution of the adaptive immune system occurred in an ancestor of the jawed vertebrates. Many of the classical molecules of the adaptive immune system (for instance, immunoglobulins and T-cell receptors) exist solely in jawed vertebrates. A distinct lymphocyte-derived molecule has been discovered in primitive jawless vertebrates, such because the lamprey and hagfish.
Type IV reactions are involved in many autoimmune and infectious diseases, but may also involve contact dermatitis. These reactions are mediated by T cells, monocytes, and macrophages. Overactive immune responses form the other finish of immune dysfunction, significantly the autoimmune problems. Here, the immune system fails to properly distinguish between self and non-self, and attacks part of the body. Under normal circumstances, many T cells and antibodies react with “self” peptides. One of the functions of specialized cells is to present younger lymphocytes with self antigens produced throughout the physique and to get rid of those cells that acknowledge self-antigens, stopping autoimmunity. Common autoimmune ailments include Hashimoto’s thyroiditis, rheumatoid arthritis, diabetes mellitus sort 1, and systemic lupus erythematosus.
Closing certain businesses and venues in England steering has been updated to indicate additional easing of restrictions for more businesses and venues to reopen from 25 July and 1 August. Public Health England has printed the Customer Logging Toolkit. This accommodates quite a lot of template materials for companies to display, as well as steering on how the policy works. Businesses must be storing the knowledge securely for 21 days and sharing it with NHS Test and Trace if asked to take action. Businesses don’t need to do anything with the knowledge.
The listing of indoor sports activities and leisure centres has been up to date to incorporate gyms. People can proceed to travel to venues or facilities that are open, however should aim to reduce the variety of journeys they make where vaporesso target mini 2 kit black possible. Organised indoor sport, bodily activity and train classes cannot take place indoors. Large outdoor events should not happen, with the exception of drive-in events.
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Author Biograhy: Nataly Komova founded Chill Hempire after experiencing the first-hand results of CBD in helping her to relieve her skin condition. Nataly is now determined to spread the word about the benefits of CBD through blogging and taking part in events. In her spare time, Nataly enjoys early morning jogs, fitness, meditation, wine tasting, traveling and spending quality time with her friends. Nataly is also an avid vintage car collector and is currently working on her 1993 W124 Mercedes. Nataly is a contributing writer to many CBD magazines and blogs. She has been featured in prominent media outlets such as Cosmopolitan, Elle, Grazia, Women’s Health, The Guardian and others.